Response of Midbrain Pain Receptors in a Rodent Model of Radiculopathy by
نویسندگان
چکیده
Response of Midbrain Pain Receptors in a Rodent Model of Radiculopathy by Priscilla Y Hwang Department of Biomedical Engineering Duke University Date:___________________________ Approved: _____________________________ Lori A Setton, Supervisor ______________________________ Warren M Grill _____________________________ David F Katz An abstract of a thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in the Department of Biomedical Engineering in the Graduate School of Duke University 2012 Copyright by Priscilla Y Hwang 2012
منابع مشابه
Concentration-Effect Relationship of Intrapritoneal Administration of 1, 25 (OH) 2-Vitamin D in a Chronic Constriction Model of Neuropathic Pain
Introduction: Results: These findings revealed the exaggerated responses in the group which received CCI. The group which was treated by 1 μg/kg of 1,25 vit D3 showed a significant reduction in pain behavior. Injection of 1,25 vit D3 did not change the response of animals to the acetone drop and von frey filament. Discussion: Our results showed that antinoceptive effect of 1,25 vit D3 in a rod...
متن کاملChanges in Midbrain Pain Receptor Expression, Gait and Behavioral Sensitivity in a Rat Model of Radiculopathy
Intervertebral disc herniation may contribute to inflammatory processes that associate with radicular pain and motor deficits. Molecular changes at the affected dorsal root ganglion (DRG), spinal cord, and even midbrain, have been documented in rat models of radiculopathy or nerve injury. The objective of this study was to evaluate gait and the expression of key pain receptors in the midbrain i...
متن کاملContribution of the Nucleus Cuneiformis to the Antinociceptive Effects of Systemic Morphine on Inflammatory Pain in Rats
Introduction: The role of midbrain reticular formation, which includes the nucleus cuneiformis (NCF), as a crucial antinociceptive region in descending pain modulation has long been investigated. In this study, we tried to highlight the role of NCF in morphine-induced antinociception in formalin-induced pain model in rats. Methods: A total of 201 male Wistar rats weighing 260-310 g were used in...
متن کاملThe Role of Parabrachial GABAA Receptors in Pain Modulation in Rats
Background & Objective: The parabrachial nucleus is a critical link in the transmission of short latency nociceptive information to midbrain neurons. GABA(A) receptors have bidirectional roles in controlling nociception and are abundant in the parabrachial region . We examined the effects of bilateral intra parabrachial microinjection of different doses of the GABA(A) receptor agonist, muscimo...
متن کاملThe role of GABAB receptors in imipramine-induced antinociception in experimental model of neuropathic pain
This study was designed to investigate the role of GABAB receptor agents on imipramine-induced antinociception in ligated and non-ligated mice using hot-plate test. The data showed that different doses of morphine (3, 6, and 9 mg/kg) induced a dose-dependent antinociception in ligated and non-ligated mice. However, the opioid response was decreased in ligated animals. Intracerebroventricular (i...
متن کامل